جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://78.39.227.9/handle/Hannan/45934
Title: Role of BRCA Gene Dysfunction in Breast and Ovarian Cancer Predisposition
Keywords: breast cancer;DNA repair;homologous recombination;ovarian cancer;tumor suppressor genes
Publisher: BioMed Central
Description: Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major hereditary breast/ovarian cancer predisposition genes, BRCA1 and BRCA2, appear to participate in a common pathway that is involved in the control of homologous recombination and in the maintenance of genomic integrity. How might such functions translate into the specific suppression of cancers of the breast and ovarian epithelia? Recent advances in the study of BRCA1 and BRCA2, discussed herein, have provided new opportunities to address this question.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138653/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10139641
Other Identifiers: Scully, Ralph. 2000. Role of BRCA gene dysfunction in breast and ovarian cancer predisposition. Breast Cancer Research 2(5): 324-330.
1465-5411
Appears in Collections:HMS Scholarly Articles

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