جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://78.39.227.9/handle/Hannan/24690
Title: A Biodegradable Polymersome Containing Bcl-xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect
Issue Date: 2013
Description: Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.
open
URI: http://creativecommons.org/licenses/by-nc-nd/2.0/kr
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201200448/abstract
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86820
Other Identifiers: Macromolecular Bioscience, Vol.13(6) : 745~754, 2013
1616-5187
OAK-2013-00702
T201301506
10.1002/mabi.201200448
Appears in Collections:College of Medicine

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