جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://78.39.227.9/handle/Hannan/24037
Title: A genome-wide association study of Hodgkin Lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21, and 10p14 (GATA3)
Authors: Enciso-Mora, Victor;Broderick, Peter;Ma, Yussanne;Jarrett, Ruth F;Hjalgrim, Henrik;Hemminki, Kari;van den Berg, Anke;Olver, Bianca;Lloyd, Amy;Dobbins, Sara E;Lightfoot, Tracy;van Leeuwen, Flora E;Försti, Asta;Diepstra, Arjan;Broeks, Annegien;Vijayakrishnan, Jayaram;Shield, Lesley;Lake, Annette;Montgomery, Dorothy;Roman, Eve;Engert, Andreas;von Strandmann, Elke Pogge;Reiners, Katrin S.;Nolte, Ilja M;Smedby, Karin E;Adami, Hans-Olov;Russell, Nicola S;Glimelius, Bengt;Hamilton-Dutoit, Stephen;de Bruin, Marieke;Ryder, Lars P;Molin, Daniel;Sorensen, Karina Meden;Chang, Ellen T;Taylor, Malcolm;Cooke, Rosie;Hofstra, Robert;Westers, Helga;van Wezel, Tom;van Eijk, Ronald;Ashworth, Alan;Rostgaard, Klaus;Melbye, Mads;Swerdlow, Anthony J;Houlston, Richard S
Issue Date: 2014
Description: To identify predisposition loci for classical Hodgkin Lymphoma (cHL) we conducted a genome-wide association study of 589 cHL cases and 5,199 controls with validation in 4 independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL; odds ratio [OR]=1.22, Pcombined=1.91×10−8), 8q24.21 (rs2019960, PVT1; OR=1.33, Pcombined=1.26×10−13) and 10p14 (rs501764, GATA3; OR=1.25, Pcombined=7.05×10−8). Furthermore, we confirmed the role of the MHC in disease etiology by revealing a strong HLA association (rs6903608; OR=1.70, Pcombined=2.84×10−50). These data provide new insight into the pathogenesis of cHL.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268499/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581091
Other Identifiers: Enciso-Mora, V., P. Broderick, Y. Ma, R. F. Jarrett, H. Hjalgrim, K. Hemminki, A. van den Berg, et al. 2014. “A genome-wide association study of Hodgkin Lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21, and 10p14 (GATA3).” Nature genetics 42 (12): 1126-1130. doi:10.1038/ng.696. http://dx.doi.org/10.1038/ng.696.
1061-4036
Appears in Collections:HSPH Scholarly Articles

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