جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://78.39.227.9/handle/Hannan/21925
Title: PM\(_{2.5}\) metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers
Authors: Cavallari, Jennifer Margaret;Eisen, Ellen A.;Fang, Shona C.;Schwartz, Joel David;Hauser, Russ B.;Herrick, Robert F.;Christiani, David C.
Issue Date: 2008
Publisher: BioMed Central
Description: Background: To better understand the mechanism(s) of particulate matter (PM) associated cardiovascular effects, research priorities include identifying the responsible PM characteristics. Evidence suggests that metals play a role in the cardiotoxicity of fine PM (PM\(_{2.5}\)) and in exposure-related decreases in heart rate variability (HRV). We examined the association between daytime exposure to the metal content of PM\(_{2.5}\) and night HRV in a panel study of boilermaker construction workers exposed to metal-rich welding fumes. Methods: Twenty-six male workers were monitored by ambulatory electrocardiogram (ECG) on a workday while exposed to welding fume and a non-workday (baseline). From the ECG, rMSSD (square root of the mean squared differences of successive intervals) was summarized over the night (0:00–7:00). Workday, gravimetric PM\(_{2.5}\) samples were analyzed by x-ray fluorescence to determine metal content. We used linear mixed effects models to assess the associations between night rMSSD and PM\(_{2.5}\) metal exposures both with and without adjustment for total PM\(_{2.5}\). Matched ECG measurements from the non-workday were used to control for individual cardiac risk factors and models were also adjusted for smoking status. To address collinearity between PM\(_{2.5}\) and metal content, we used a two-step approach that treated the residuals from linear regression models of each metal on PM\(_{2.5}\) as surrogates for the differential effects of metal exposures in models for night rMSSD. Results: The median PM\(_{2.5}\) exposure was 650 μg/m\(^3\); median metal exposures for iron, manganese, aluminum, copper, zinc, chromium, lead, and nickel ranged from 226 μg/m\(^3\) to non-detectable. We found inverse linear associations in exposure-response models with increased metal exposures associated with decreased night rMSSD. A statistically significant association for manganese was observed, with a decline of 0.130 msec (95% CI: -0.162, -0.098) in night rMSSD for every 1 μg/m\(^3\) increase in manganese. However, even after adjusting for individual metals, increases in total PM\(_{2.5}\) exposures were associated with declines in night rMSSD. Conclusion: These results support the cardiotoxicity of PM\(_{2.5}\) metal exposures, specifically manganese. However the metal component alone did not account for the observed declines in night HRV. Therefore, results suggest the importance of other PM elemental components.
URI: Cavallari, Jennifer M., Ellen A. Eisen, Shona C. Fang, Joel Schwartz, Russ Hauser, Robert F. Herrick, and David C. Christiani. 2008. PM\(_{2.5}\) metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers. Environmental Health 7: 36.
1476-069X
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481261/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:4879858
Appears in Collections:HSPH Scholarly Articles

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