جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://78.39.227.9/handle/Hannan/18199
Title: Trifluoroacetic acid: A more effective and efficient reagent for the synthesis of 3-arylmethylene-3,4-dihydro-1H-quinolin-2-ones and 3-arylmethyl-2-amino quinolines from Baylis-Hillman derivatives via Claisen rearrangement
Authors: Pathak, Richa;Madapa, Sudharshan;Batra, Sanjay
Keywords: Baylis-Hillman;TFA;Claisen rearrangement;3-arylmethyl-3,4-dihydro-1H-quinolin-2-one;2-amino-3-arylmethyl-quinoline
Issue Date: 2007
Description: Trifluoroacetic acid has been discovered to be a highly effective and efficient reagent for the tandem Claisen rearrangement and cyclisation reaction to yield 3-arylmethylene-3,4-dihydro-1H-quinolin-2-ones from compounds obtained from the SN2 reaction between anilines and acetyl derivatives of Baylis-Hillman adducts of acrylates in the presence of DABCO. In contrast similar compounds obtained from the acetyl derivatives of Baylis-Hillman adduct of acrylonitrile on treatment with trifluoroacetic acid directly furnish 3-arylmethyl-2-amino-quinoline via tandem Claisen rearrangement, cylisation and isomerisation.
URI: Tetrahedron, 63, 363-370 (2007)
http://hdl.handle.net/123456789/37
Appears in Collections:Medicinal and Process Chemistry

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